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Changed handwriting
If your handwriting starts to go from big and loopy to small and cramped, this could be an early warning sign of Parkinsonās disease. āTeachers with Parkinsonās will notice students complaining that they canāt read their handwriting when they write on the blackboard,ā says Deborah Hall, MD, a neurologist at Rush University Medical Center in Chicago. Look for letters getting smaller and words crowding together. Many patients have slower movement and trouble with repetitive tasks, like handwriting.

Reduced sense of smell
If youāre having trouble smelling pungent foods or no longer pick up your favorite scents, see a doctor. Itās not the most common symptom of Parkinsonās, but Dr. Hall says patients who suffer a loss of smell report it being the earliest sign they experience. The link between reduced sense of smell and Parkinsonās isnāt clear, but one theory is that the clumps of the protein alpha-synuclein, found in the brains of all Parkinsonās patients, may form in the part of the brain responsible for smell before migrating to other areas and affecting motor function.

Trouble sleeping
If you were once a peaceful sleeper, but now toss and turn, flail your limbs, or even fall out of bed, it could indicate Parkinsonās. Itās normal to have an occasional restless night, but talk to your doctor if you or your partner notices extra movement when youāre in a deep sleep, or if you start sleep-talking. More research is needed to discover why disturbed sleep and Parkinsonās are related, but one theory is that the degeneration of specific regions of the brain stem that can cause disordered sleeping may play a role in other Parkinsonās symptoms.

Constipation
If youāre not moving your bowels every day, or are increasingly straining, this can be an early sign of Parkinsonās. The disease alters the bodyās autonomic nervous system, which controls processes like digestion and bowel function. Constipation on its own isnāt unusual, but if youāre experiencing other symptoms like difficulty sleeping and trouble moving or walking, talk to your doctor.

Depression
Much has been made of the link between the late comedian Robin Williamsā Parkinsonās diagnosis and ongoing battle with depression. Sometimes patients can develop depression after learning they have Parkinsonās, but itās also common for people to be depressed years before they start to exhibit physical symptoms, says Michele Tagliati, MD, director of the Movement Disorders Program at Cedars-Sinai Medical Center in California. āParkinsonās is characterized as a movement disorder because of a lack of dopamine in the brain, but there are also low levels of other neurotransmitters like serotonin, which are intimately related to depression,ā he says. Parkinsonās patients who are depressed tend to feel apathetic and generally disinterested in things they used to enjoy, compared to feeling intensely sad or helpless, as is common in primary depression. āThey lose pleasure in the simple things of life, like waking up in the morning and buying the paper,ā says Dr. Tagliati. Treatment for depression includes counseling, antidepressant medication, and in the most extreme cases, electric shock therapy.

Tremors or shaking when relaxed
Shaking can be normal after lots of exercise or if youāre anxious, or as side effect to some medications. But a slight shake in your finger, thumb, hand, chin, lip, or limbs when your body is at rest and your muscles are relaxed could be a sign of Parkinsonās, according to the National Parkinson Foundation. About 70 percent of people with the disease experience a resting tremor, and it can become more noticeable during stress or excitement. These are the most common symptom and often tip people off to the disease, but when Parkinsonās patients think back they realize they experienced loss of smell, disturbed sleep, or anxiety before the tremors began.

Stiffness and slowed movements
Watch for an abnormal stiffness in your joints along with muscle weakness that doesnāt go away and makes everyday tasks like walking, teeth brushing, buttoning shirts, or cutting food difficult. If you no longer swing your arms when walking, your feet feel āstuck to the floorā (causing you to hesitate before taking a step), or people comment that you look stiff when you havenāt been injured, the National Parkinson Foundation suggests seeing a doctor.

Softer voice, or masked face
Doctors say that a softer voice or masked, EĆĻréŔŔionless face is a common sign of the disease. Some patients may also talk softer without noticing or have excessively fast speech or rapid stammering. Parkinson's causes disruption of movement, including facial muscles.